Novel Synthetic Chalcones Display Potent Anti- Leishmania ( Viannia ) braziliensis Profile and Inhibit Proteolytic Activities
American Tegumentary Leishmaniasis, primarily caused by Leishmania (Viannia) braziliensis, remains a major public health challenge in Latin America. The variable efficacy and toxicity of pentavalent antimonials underscore the urgent need for new therapeutic candidates. Among the compounds currently explored, chalcone...