Author

Frédérick A. Mallette

2 papers indexed here

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Open access Sep 2026

eIF4A inhibition disrupts resistance-associated translational and metabolic programs in BRAF-mutant melanoma

Acquired resistance to mitogen-activated protein kinase (MAPK) pathway inhibitors remains a major barrier to durable control of BRAF-mutant melanoma. Although resistance mechanisms are heterogeneous, they converge on adaptive programs that support survival, phenotypic plasticity, and metabolic fitness. We asked whether...

Alejandro Schcolnik-Cabrera, Meriem Takdenti, Anavasadat Sadr Hashemi Nejad et al. · bioRxiv · 0 citations

Open access Aug 2026

SMOC2 promotes partial epithelial-to-mesenchymal transition and maladaptive repair in renal tubular epithelial cells.

Chronic kidney disease is a global health concern characterized by maladaptive repair processes leading to kidney fibrosis. Following injury, early alterations in the extracellular matrix precede the development of kidney fibrosis and represent potential therapeutic targets to improve kidney repair. In this context, st...

Schrodinger Cenatus, Peng Gao, Nathalie Henley et al. · JCI Insight · 0 citations