Open access
Oct 2026
Integrative single-cell and bulk transcriptomics with reverse network pharmacology prioritizes macrophage-associated candidate genes in Lyme arthritis
Introduction Lyme arthritis (LA) involves complex immune dysregulation, and macrophages contribute centrally to persistent joint inflammation. However, synovial macrophage heterogeneity and its potential relevance to therapeutic intervention remain incompletely defined. Methods We integrated scRNA-seq data from Borreli...
Yan Dong, Yan-Shuang Luo, Yan-Tong Chen et al.
· Frontiers in Immunology · 0 citations