Author

Fu-Heng Xie

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Open access Aug 2026

PC1-guided transcriptomic stratification reveals hepatic transcriptional heterogeneity and defines a myeloid-associated 20-gene signature

Hepatic lipid-associated inflammation contributes to metabolic liver disease and cardiometabolic complications. Treatment-based transcriptomic comparisons can obscure inter-individual heterogeneity when animals exposed to the same experimental condition show divergent molecular responses. In the public hyperlipidemic l...

Zihan Li, Fu-Heng Xie, Yu-Qing He et al. · bioRxiv · 0 citations

Jul 2026

Single-blastomere transcriptomics identifies NR5A2-associated metabolic genes during porcine zygotic genome activation.

Findings identify candidate metabolic genes that may inform future optimization of in vitro culture media to enhance the developmental competence of porcine embryos and warrant subsequent functional validation.

Zihan Li, Fu-Heng Xie, Yu-Qing He et al. · Theriogenology · 0 citations