Bioinformatics-driven discovery and cross-cohort validation of a two-gene signature (RPH3A and HIGD1B) associated with Alzheimer's disease.
BACKGROUND Transcriptomic biomarker discovery for Alzheimer's disease (AD) has yielded numerous candidate signatures, yet many fail independent external validations due to overfitting or cohort-specific confounders. We aimed to identify a minimal reproducible gene signature and evaluate its generalizability under locke...