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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Fushun Zhang

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Open access Sep 2026

Structural mechanisms of SAMD9 autoinhibition and pathogenic dysregulation

SAMD9 and SAMD9L (SAMD9/9L) are large cytosolic proteins essential for hematopoietic homeostasis and antiviral defense (1–3). Germline gain-of-function (GoF) mutations in SAMD9/9L cause severe multisystem disorders and predispose to leukemia, but the mechanisms that regulate SAMD9/9L activity and how pathogenic mutatio...

Z. Mou, Fu-Shun Zhang, Marisol Morales et al. · 0 citations
Open access May 2026

Recovery of proofreading-impaired SARS-CoV-2 reveals a mutator phenotype and an ExoN activity threshold for viability

This work indicates that SARS-CoV-2 can tolerate substantial impairment of proofreading but only when residual exonuclease activity remains above a minimal threshold, and defines this activity threshold to help guide antiviral strategies that target coronavirus proofreading.

Li He, Yuan-Wei Norman Su, Fushun Zhang et al. · 0 citations

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