Immune-instructive baicalin-loaded nanofibrous membranes regulate macrophage polarization via PI3K/AKT/GSK3β signaling for enhanced cutaneous wound healing.
Chronic cutaneous wounds remain a major clinical challenge due to a persistent pro-inflammatory microenvironment characterized by unresolved inflammation and dysregulated macrophage polarization. Emerging "immune-instructive" biomaterials offer a promising strategy to actively modulate host immune responses rather than...