Fumihiro Sugiyama

Heterozygous disruption of Snrpf causes post-implantation embryonic lethality with RNA splicing perturbation in mice.

RNA splicing is a post-transcriptional modification process of precursor mRNA. This process is regulated by the macromolecular complex known as the spliceosome. One of the major components of spliceosomes is the small nuclear ribonucleoprotein (snRNP). Snrpf encodes SmF, a core protein component of the snRNP. Although...