Fu-Quan Zhang

Evaluating the causal effects of circulating metabolites on major depression disorder.

Exploring the impacts of type 2 diabetes and metformin use on Parkinson’s disease: Mendelian randomization analysis and a national cohort study

Neuroimmune lipidome dysregulation in major depressive disorder: A meta-analysis of peripheral endocannabinoid and n-acylethanolamine signaling.

Major depressive disorder (MDD) is a prevalent psychiatric condition characterized by substantial biological heterogeneity. Evidence suggests that the endocannabinoid system (ECS), which regulates stress responses, emotional processing, and neuroimmune signaling, may contribute to depression pathophysiology. However, c...

Exploring the Causal Role of Circulating Inflammatory Proteins in Multiple Sclerosis: A Mendelian Randomization Study and Druggability Analysis.

Genetic evidence linking inflammatory proteins to MS pathogenesis was uncovered, offering clues for novel therapeutic targets for this condition and strengthening the biological plausibility of inflammation-driven disease mechanisms.

Association between antidepressant use and the risk of type 2 diabetes: a multi-stage Mendelian randomization study.

Genetic evidence suggesting medication-specific associations between antidepressant use liability and T2D susceptibility is provided, highlighting that the metabolic effects of individual antidepressants may vary, thus, warranting further studies to determine the clinical relevance of the findings.