Minimal CBX3-Derived UCOE Confers Long-Term Resistance to Transgene Silencing in Human iPSCs During Neuronal Differentiation
Long-term transgene silencing remains a major challenge in lentiviral gene delivery, particularly in pluripotent stem cells undergoing lineage-specific differentiation. Universal chromatin opening elements (UCOEs) have emerged as effective regulatory elements for protecting transgene expression against epigenetic silen...