Standard polygenic risk scores capture overall genetic liability to coronary artery disease (CAD) but do not reveal the biological processes contributing to risk in an individual. Here, we applied data-driven latent factor decomposition to 526 genome-wide significant CAD-associated variants, using their associations wi...
J. Morze, K. Smith, M. Kierczak et al.· medRxiv· 0 citations
All apolipoprotein B (apoB)-containing lipoproteins are causal risk factors for coronary artery disease (CAD). However, triglyceride-rich lipoproteins (TRL) and lipoprotein(a) [Lp(a)] exhibit greater per-particle atherogenicity than low-density lipoprotein (LDL) through mechanisms that remain incompletely underst...
J. Morze, E. Bjornson, Michael Y. Mi et al.· European Heart Journal· 0 citations
AVC in this middle-aged population cohort was associated with a substantially higher and more advanced coronary atherosclerotic burden, including mixed calcified and non-calcified plaque, beyond traditional risk factors alone.
A. Fayad, A. Gottlieb, K. Feldt et al.· European Heart Journal· 0 citations
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