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Sep 2026

Abstract B075: Harnessing Tumor-Penetrating Peptides to Modulate the Pancreatic Tumor Immune Microenvironment

Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate of approximately 13% and remains largely resistant to immunotherapy because its dense fibrotic stroma restricts drug penetration, and its immunosuppressive tumor microenvironment (TME) limits anti-tumor immunity. Novel strategies are urgently needed t...

Shawn A. Abeynaike, In Hwan Park, Ashley Martinez et al. · 0 citations
Sep 2026

Abstract B090: Defining The Immune Mechanisms Required For iRGD-guided Low Dose IL-2 Therapy in Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PCAD) remains one of the deadliest cancers with minimal treatment options, highlighting the need for more effective immunotherapeutic strategies capable of overcoming its highly immunosuppressive tumor microenvironment. Tumor penetrating peptides such as iRGD enhance the delivery and...

M. Harari, In Hwan Park, Shawn A. Abeynaike et al. · 0 citations

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