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Open access Sep 2026

Declines in Plasma Erythritol and Improvements in Cardiovascular Risk and Atherogenic Lipid Profiles: A 2-Year Randomized Weight-Loss Dietary Intervention Trial.

BACKGROUND High circulating levels of sugar alcohols (polyols) have recently been linked to increased risks of cardiovascular events. OBJECTIVES We investigated whether temporal changes in plasma levels of erythritol and other isomeric polyols (arabitol/xylitol and mannitol/sorbitol) in response to weight-loss dietar...

Yoriko Heianza, Jennifer C. Rood, Catherine M. Champagne et al. · 0 citations
Open access Sep 2026

Blood Metabolomic Signatures of One-Hour Glucose Predict Cardiometabolic Risk

Background: Elevated 1-hour glucose levels during an oral glucose tolerance test (OGTT) strongly predict type 2 diabetes (T2D) and cardiovascular disease. We investigated whether fasting blood metabolome predicting 1-hour glucose could be a target for improving β-cell function, long-term glycemic trajectories, and redu...

Yoriko Heianza, Ming-Hao Kou, Xuan Wang et al. · 0 citations

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