Characterization and quantitation of urinary metabolites of 2-monochloropropane-1,3-diol (2-MCPD) in Wistar rats.
Fatty acid esters of 2-monochlorpropane-1,2-diol (2-MCPD) are process contaminants formed during the heat treatment of foodstuffs containing fat and salt. The limited information on 2-MCPD metabolism hinders investigating the mechanisms of toxic effects observed in skeletal and heart muscle as well as kidneys of rats t...