LC–MS/MS Method Development and Validation for Quantification of Repotrectinib in Rat Plasma and its Application to Pharmacokinetic Study
Objective: Repotrectinib is a next-generation tyrosine kinase inhibitor (TKI) recommended for adults with ROS1-positive, locally advanced or metastatic non-small cell lung cancer (NSCLC). The present study aimed to develop and validate a sensitive LC-MS/MS method for quantifying repotrectinib in rat plasma. Methods: An...