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Clinical trial Open access Aug 2026

Physical exercise for prevention of dementia study: a 48-month randomized controlled trial

Background Although multimodal exercise interventions are recognized for their potential to attenuate age-related cognitive decline, the current literature lacks longitudinal depth. Specifically, robust randomized evidence addressing the long-term efficacy of structured training protocols remains limited. This single-b...

E. Iuliano, G. Fiorilli, A. Angiolillo et al. · 0 citations
Open access Sep 2026

Intrinsic capacity is associated with cardiovascular rehabilitation outcome in older adults: a multidimensional comparison with frailty.

OBJECTIVES To test whether Intrinsic Capacity (IC), a construct centred on individuals' positive physical and mental attributes, is associated with functional outcome in older adults undergoing Cardiac Rehabilitation (CR), and to compare its predictive value with Frailty Index (FI), a deficit-accumulation model. DESI...

L. Bencivenga, Annachiara Vassallo, G. Curcio et al. · 0 citations
Open access Jul 2026

Assessment of Causes and Potential Prevention and Therapy for Autoimmune Diseases Through Evolutionary Medicine

Autoimmune diseases comprise a broad group of conditions that affect virtually any organ or tissue and share mechanisms of chronic, autoimmune-based inflammation. Once rare or unknown, they have become increasingly common in recent years, affecting individuals of all ages, including the elderly, due to the growing numb...

G. Libertini, G. Corbi, Valeria Conti et al. · 0 citations

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