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Author

G. De Simone

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Open access Oct 2026

Virtual Brain Modelling Reveals Altered Network Dynamics and Predicts Symptom Severity in Schizophrenia: Relevance to Antipsychotic Treatment Response and Resistance

Background Schizophrenia (SZ) is a heterogeneous disorder characterized by positive, negative, cognitive and disorganisation symptoms, with pleomorphic phenotype and poorly understood aetiology. Dopamine dysregulation represents the most replicated in vivo pathophysiology finding. However, accumulating evidence suggest...

Matteo Vitacca, D. Pischedda, M. Ciccarelli et al. · 0 citations
Open access Sep 2026

681. Transcranial magnetic stimulation reveals altered GABAergic and glutamatergic activity in treatment-resistant schizophrenia

TRS is characterized by the most severe impairments in GABA-A receptor-mediated inhibition and the highest levels of cortical hyperexcitability and inhibitory deficits, alongside shared plasticity impairments across schizophrenia subtypes.

A. Barone, G. Senerchia, G. De Simone et al. · 0 citations
Open access Aug 2026

A Potential Link Between Dyslipidemia and Inflammation in Patients with Schizophrenia: Insights from Sterols and HDL Profile Analysis

The impaired cholesterol metabolism in SCZ patients is associated with a pro-inflammatory state, which is responded to by the anti-inflammatory remodeling of HDL subfractions, and improving intestinal cholesterol absorption and reducing endogenous cholesterol biosynthesis could represent putative therapeutic approaches...

S. Bagnasco, G. De Simone, G. Cernera et al. · 0 citations
Review Open access Sep 2026

Addressing fusiform gyrus dysfunction in schizophrenia, theory of mind, and implications for antipsychotics' response and resistance: A systematic review and critical appraisal.

The Fusiform Gyrus appears to function as a dynamic, state-sensitive hub underlying perceptual, emotional, and cognitive disturbances in schizophrenia, in line with impaired ToM.

M. Ciccarelli, B. Mazza, A. Nasti et al. · 0 citations

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