Open access
Jul 2026
Anti-capsid nanobodies function as HIV-1 capsid inhibitors by intracellular capsid degradation.
Antiretroviral therapy (ART) strategies against HIV-1 have been successful in suppressing HIV-1 replication and preventing disease progression. However, drug-resistance development, side-effects and life-long adherence of current drugs have driven the development of novel inhibitors against HIV-1. Inhibition of capsid...
F. M. Stel, Charlotte E J Verkuijlen, E. Zijlstra-Willems et al.
· Communications Biology · 1 citation