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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

G. Deyab

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Open access Sep 2026

The Parkinson 's Disease Associated BAP1/ASXL3 Complex Regulates the Internalization of α-Synuclein Fibrils by Reprogramming the Cell Surface Glycoproteome

A central hallmark of Parkinson's disease (PD) is the spread of -Synuclein (-Syn) aggregates, which is thought to contribute to its progressive nature. To better understand the mechanism of cellular internalization of -Syn fibrils, we conducted a genome wide CRISPR activation (CRISPRa) screen to identify genetic modifi...

N. Karpilovsky, T. Goiran, K. Senkevich et al. · 0 citations

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