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Open access Oct 2026

Synthesis and Cytotoxic Activity of 1,3‐Selenazole‐2‐Amine Derivatives With Computational ADMET Profiling

A set of newly developed 1,3‐selenazole‐2‐amine derivatives (1–4) was prepared via a modified Hantzsch‐type cyclization of appropriately substituted α‐bromoacetophenones with selenourea under reflux conditions. The synthesized compounds were tested for cytotoxic activity in HT‐29 (colon cancer), MCF‐7 (breast cancer),...

G. Dilek, S. Akkoç · 0 citations
Open access Aug 2026

Comprehensive Investigation of Benzimidazolium Derivatives Through Synthesis, Characterization, Cytotoxicity Activity, Immunocytochemistry, and ADME and Toxicity Analyses

The results indicated that the compounds possess high lipophilicity but show limited bioavailability due to low solubility and none of the compounds were predicted to cross the blood–brain barrier, which limits their potential for direct effects on the central nervous system.

G. Dilek, Senem Akkoç · 0 citations

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