Regiodivergent Oxyfuctionalization of Non-natural Tricyclic Terpenoids Using Sequence Divergent Unspecific Peroxygenases (UPOs)
Unspecific peroxygenases (UPOs) catalyze the H2O2-dependent monooxygenation of organic substrates with regioselectivity and chemoselectivity; however, their application to sterically demanding, non-natural terpene skeletons has remained largely unexplored to date. Here, we present a computationally-guided, multiparam...