Diabetic hepatopathy is a major complication of type 2 diabetes mellitus characterized by metabolic dysregulation, oxidative stress, inflammation, and emerging evidence of ferroptosis-mediated liver injury. Icariin (IC), a bioactive flavonoid, exhibits hepatoprotective potential; however, its clinical applicability is...
B. Hifni, S. A. Alyamani, Nasser S. Alqahtani et al.· BMC Pharmacology and Toxicol...· 0 citations
Arsenic (AR) is an environmental and mining occupational toxicant with reported hepatotoxic effects. Ferroptosis has recently emerged as a critical mechanism involved in arsenic-induced hepatotoxicity. This study investigated the hepatoprotective effects of puerarin (PU) and its PLGA-loaded nanoparticle formulation (PU...
S. A. Alyamani, B. Hifni, Nasser S. Alqahtani et al.· BMC Pharmacology and Toxicol...· 0 citations
Overall, ROS fortification at a level of 1% is recommended for Nile tilapia especially during TEB exposure, as ROS dietary intervention improved Nile tilapia growth and restored the intestinal histomorphology and gene expression.
Rowida E. Ibrahim, G. Elshopakey, Abdallah Tageldein Mansour et al.· Journal of animal physiology...· 0 citations
In DMH-exposed rats, MOR-Lips were associated with more favorable redox, inflammatory, proliferative, apoptosis-related, autophagy-related, and histopathological profiles than free MOR, which supports further investigation of MOR-Lips as a formulation strategy for improving the biological activity of morin.
Mohammed A. Akeel, E. Elmorsy, F. Alshammari et al.· Pharmaceuticals· 0 citations
HES and HES-PLGA-NPs were associated with multi-mechanistic protection against cisplatin-induced oxidative, inflammatory, apoptotic, and ferroptosis-associated damage in the testes, and may represent a promising nanoantioxidant candidate warranting further investigation for preserving male reproductive function during...
Mohammed A. Akeel, E. Elmorsy, Aly A. M. Shaalan et al.· Antioxidants· 0 citations
This work investigates the potential protective effects of the diatom Amphora coffeaeformis as a feed additive against the deleterious effects (primarily on immune organs) of cypermethrin (CYP) in Nile tilapia, Oreochromis niloticus, with respect to hematology, immune/antioxidant parameters, biochemical indices, proinf...
Elsayed A. A. Eldessouki, G. Elshopakey, Mai A. M. El‐Son et al.· Developmental and Comparativ...· 0 citations
Overall, BPP (20 g/kg) may protect O. niloticus against OXY-induced liver damage through its antioxidant potential, supporting its application as a functional additive in aquaculture.
Afaf N. Abdel Rahman, G. Elshopakey, A. Mansour et al.· Veterinary research communic...· 0 citations
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