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Author

G. F. Hatfull

2 papers indexed here

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Sep 2026

Ag85A-Dependent Surface Lipid Remodeling Impairs Adhesion and Infection of Therapeutic Mycobacteriophage

Patients infected with mycobacteria, particularly Mycobacterium abscessus, frequently experience antibiotic treatment failure. Phage therapy, used under compassionate care, offers a promising alternative and has already demonstrated clinical efficacy. However, phage-bacteria interactions and their coevolution remain...

M. Illouz, Valentin Wasselin, Adrián Pál et al. · 0 citations
Open access Sep 2026

Mycobacteriophage Adephagia gp48 inhibits essential host cell wall biosynthesis enzyme mannose-1-phosphate guanylyltransferase

It is common for bacteriophages to encode proteins that are strongly inhibitory to growth of the bacterial host, and about 10% of mycobacteriophage-encoded proteins have this property. Adephagia is a Cluster K1 mycobacteriophage and prior cloning and expression of 66 Adephagia non-structural genes identified 14 that ar...

Michael J. Lauer, K. Freeman, Da Jiang et al. · 0 citations

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