Open access
Sep 2026
A pericyte-to-myofibroblast transition links APOE4 to cerebrovascular degeneration.
Cerebrovascular disease is a major but poorly understood feature of Alzheimer's disease (AD). The strongest genetic AD risk factor, apolipoprotein E4 (APOE4), is associated with cerebrovascular degeneration, including vascular amyloid deposition and fibrosis. To uncover how APOE4 promotes cerebrovascular pathology, we...
B. Schuldt, Dominic Haworth-Staines, Andrea Perez-Arevalo et al.
· Cell · 0 citations