The cross‐NAb landscape in a real‐world Chinese population after a 3‐year zero‐COVID strategy is defined, showing modest broadening of humoral immunity following multiple exposures, but antigenic divergence of emerging Omicron sub‐variants continues to limit cross‐protection, supporting the need for variant‐adapted vac...
Ting Yang, Rong Zhang, Shi-Jie Qin et al.· Journal of Medical Virology· 0 citations
Mechanistic studies reveal that NTD-5 and NTD-9 antibodies neutralize by inducing S1 shedding, thereby extending this mechanism to selected NTD-directed antibodies and providing a structural and mechanistic framework for rational vaccine and antibody design resilient to antigenic drift.
Jian-Jie Zhou, Wen-Yu Li, Xiaoyu Wang et al.· Proceedings of the National...· 0 citations
The split intron-exon (SIE) system is introduced, which separates ribozymes from substrates to facilitate the efficient production of modified circular RNAs, optimizing production process.
Lei Wang, Qiaoli Zhai, Chunbo Dong et al.· Nature Communications· 0 citations
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