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G. Gao

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Review Open access Sep 2026

Cross‐Neutralization Responses and Persistent Symptoms After SARS‐CoV‐2 Breakthrough Infections

The cross‐NAb landscape in a real‐world Chinese population after a 3‐year zero‐COVID strategy is defined, showing modest broadening of humoral immunity following multiple exposures, but antigenic divergence of emerging Omicron sub‐variants continues to limit cross‐protection, supporting the need for variant‐adapted vac...

Ting Yang, Rong Zhang, Shi-Jie Qin et al. · 0 citations
Open access Aug 2026

A structural and mechanistic atlas of NTD antibody neutralization and immune escape across SARS-CoV-2 prototype and its (sub-)variants.

Mechanistic studies reveal that NTD-5 and NTD-9 antibodies neutralize by inducing S1 shedding, thereby extending this mechanism to selected NTD-directed antibodies and providing a structural and mechanistic framework for rational vaccine and antibody design resilient to antigenic drift.

Jian-Jie Zhou, Wen-Yu Li, Xiaoyu Wang et al. · 0 citations
Open access Jul 2026

Split intron-exon system for circular RNA synthesis

The split intron-exon (SIE) system is introduced, which separates ribozymes from substrates to facilitate the efficient production of modified circular RNAs, optimizing production process.

Lei Wang, Qiaoli Zhai, Chunbo Dong et al. · 0 citations

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