Author

Guo-An Gao

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Open access Nov 2026

Single-cell transcriptome-wide association analysis reveals epithelial cell-specific genetic susceptibility to colorectal cancer

Bulk-tissue transcriptome-wide association studies (TWAS) have identified colorectal cancer (CRC) susceptibility genes, but cell-type-specific regulatory mechanisms remain poorly understood. Here, we performed single-cell TWAS integrating matched germline genotypes and single-cell transcriptomes from normal colorectal...

Q. Li, C. Li, L. Lyu et al. · medRxiv · 0 citations

Sep 2026

Syntaxin 1 A knockdown suppresses hepatocellular carcinoma cell viability and invasion but induces apoptosis primarily through the AKT pathway.

OBJECTIVE Syntaxin 1 A (STX1A) was recently shown to regulate the progression of several cancers. However, the role of STX1A in hepatocellular carcinoma (HCC) remains unclear. We examined how STX1A affects HCC cell behavior and its relationship to the AKT and ERK pathways. METHODS The clinical implications of STX1A i...

Jun-Duo Hu, Guo-An Gao, Ying-Li Zhou et al. · Tissue & Cell · 0 citations

Guo-An Gao

Single-cell transcriptome-wide association analysis reveals epithelial cell-specific genetic susceptibility to colorectal cancer

Syntaxin 1 A knockdown suppresses hepatocellular carcinoma cell viability and invasion but induces apoptosis primarily through the AKT pathway.

Syntaxin 1 A knockdown suppresses hepatocellular carcinoma cell viability and invasion but induces apoptosis primarily through the AKT pathway.