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Author

G. Garcia-Manero

h-index 19 View on Semantic Scholar

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Open access Aug 2026

Clinical outcomes associated with NPM1 mutations in newly diagnosed acute myeloid leukemia

Nucleophosmin 1‐mutated (NPM1mt) acute myeloid leukemia (AML) is associated with a relatively favorable prognosis though long‐term outcomes remain suboptimal without clear predictors identified by therapy.

Aziz Farhat, Georgina El Hajjar, H. Kantarjian et al. · 1 citation
Jul 2026

The novel hypomethylating agent NTX-301 reprograms epigenetic and Hippo signaling pathways and exhibits pre-clinical activity in venetoclax-resistant and TP53-mutant AML.

Data suggest that NTX-301 exerts potent anti-leukemia activities superior to 5-AZA and synergizes with VEN in VEN-resistant and TP53-mutant AML, in part by suppressing DNMT1 and inducing DNA damage responses and apoptosis, by inducing p53 signaling and demethylating LATS1/2, thus activating Hippo signaling.

B. Carter, P. Mak, Suresh Satpati et al. · 0 citations

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