Open access
Aug 2026
Nanoparticles-mediated dual drug administration boosts therapeutic efficacy in drug resistant melanoma.
A dual-drug delivery system co-loading trametinib, MEK inhibitor, and alisertib, Aurora A kinase inhibitor was developed, optimized to maintain a previously established synergistic ratio which effectively overcome acquired resistance to standard-of-care therapies and induce durable tumor regression.
Giulia Lovati, Pietro Milesi, Paolo Fossati et al.
· Journal of Controlled Releas... · 0 citations