G. Guha

Alzheimer's disease as a disorder of time-gated clearance: Circadian regulation of Glymphatic function in neurodegeneration.

This work proposes a time-gated clearance framework in which temporally misaligned or insufficient waste removal contributes to protein accumulation and disease progression and discusses therapeutic implications of circadian re-entrainment, sleep optimization, BBB restoration, vascular protection, and enhancement of gl...