Head and neck squamous cell carcinoma (HNSCC) has exceptionally high recurrence rates, exceeding 50%, contributing to mortality and morbidity. This recurrence rate is proposed to be due to field cancerization, a phenomenon where tumor-adjacent “field” tissue that appears histologically normal harbors molecular changes...
Claire B. Mills, Yin Huang, Chan-Mi Lee et al.· bioRxiv· 0 citations
Lineage plasticity underlies therapeutic resistance in cancer1,2, yet the translational mechanisms that enable this phenotypic flexibility remain largely unknown. Here using prostate cancer as a model of lineage dependence, we performed unbiased small RNA sequencing and identified tRNA1Arg(UCU) as a regulator of lineag...
Y. Kim, Sonali Arora, D. Young et al.· Nature· 0 citations
It is shown that metastasis-to-metastasis seeding is the dominant pattern of cancer spread and that increased polyclonal migration predicts poor prognosis, and that post-mortem cell-free DNA captures genomic and transcriptional heterogeneity of the subtypes, which provides a potential strategy for noninvasive assessmen...
P. Itagi, Samantha L. Schuster, Sonali Arora et al.· Nature· 0 citations
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