Switching apo- and holo-IscR control of LcrF alters how iron and oxygen regulate Yersinia virulence factors
ABSTRACT Iron and oxygen availability fluctuate spatially across mammalian tissues as well as temporally during bacterial infection. The [2Fe-2S] cluster-coordinating transcription factor IscR senses changes in iron and oxygen levels and plays a pivotal role in how Yersinia, Salmonella, and Vibrio regulate critical vir...