Genotype-by-regional ancestry proxy interactions at 8q24 reveal association heterogeneity in prostate cancer risk.
The 8q24 region is a major prostate cancer susceptibility locus, but variant effects may differ across ancestry-associated haplotype contexts. We analyzed whole genome sequencing and electronic health record data from 166,155 male participants in the NIH All of Us Research Program (10,166 cases and 155,989 controls). A...