Biomolecular interactions trigger structural changes of protein complexes essential for cellular signaling, regulation, and drug action [1–4]. Modern co-folding models can now generate detailed structures of multi-component complexes directly from sequence [5–9]. However, recent evaluations reveal that they frequently...
Protein kinases are critical regulators of cellular signaling, but precise modulation of their activity remains challenging due to their high structural conservation. Here, we present de novo designed genetically encoded miniproteins capable of activating or inhibiting focal adhesion kinase (FAK) by directly targeting...
Magnus S. Bauer, Saurav Kumar, Mia S. Donald-Paladino et al.· bioRxiv· 0 citations
Protein kinases are critical regulators of cellular signaling, but precise modulation of their activity remains challenging due to their high structural conservation. Here, we present de novo designed genetically encoded miniproteins capable of activating or inhibiting focal adhesion kinase (FAK) by directly targeting...
Magnus S. Bauer, Saurav Kumar, Mia S. Donald-Paladino et al.· bioRxiv· 0 citations
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