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Author

G. Leonenko

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Open access Oct 2026

Mapping polygenic risk scores to brain cells: insights for neurodegenerative diseases

Neurodegenerative diseases (NDDs) are driven by multiple related yet distinct pathological processes that evolve over decades, resulting in substantial clinical and neuropathological heterogeneity. Postmortem examinations of older individuals frequently reveal multiple coexisting neuropathologies, however, the underlyi...

E. Simmonds, A. Mckeever, U. Yaman et al. · 0 citations
Open access Sep 2026

Genetic Resilience and Resistance in Alzheimer's Disease Diagnosis and Pathology.

A brain maintenance mechanism that supports the brain's ability to resist to changes in neuronal integrity is suggested, suggesting a brain maintenance mechanism that supports the brain's ability to resist to changes in neuronal integrity in Alzheimer's disease.

G. Leonenko, K. Mavromati, Lynn Hughes et al. · 0 citations
Open access Aug 2026

Multivariate blood biomarkers capture resilience and resistance phenotypes across the Alzheimers disease spectrum

A multivariate blood-based framework integrating 19 molecular assays and six risk instruments in the Bio-Hermes-001 cohort supports resilience and resistance as molecularly distinct subgroups and provides a scalable framework for pathology-informed stratification and mechanistic investigation.

K. Mavromati, C. Dalby, A. Dibble et al. · 0 citations

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