SPAK regulates myocardial chloride homeostasis and drives dilated cardiomyopathy through mitochondrial dysfunction and energy metabolic disruption
Dilated cardiomyopathy (DCM) is a major cause of heart failure and sudden cardiac death, with myocardial ion homeostasis imbalance and mitochondrial dysfunction as core pathological mechanisms. However, the regulatory role of chloride (Cl⁻) homeostasis and its key mediators in DCM remains unclear. Ste20-related p...