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Open access Oct 2026

Interleukin-6 predicts cardiovascular events beyond standard modifiable risk factors in individuals without atherosclerotic cardiovascular disease

Current risk stratification algorithms capture high-risk individuals with classical risk factors or established atherosclerotic cardiovascular disease (ASCVD). However, a clinically relevant proportion of individuals without threshold levels of standard modifiable risk factors (SMuRF) – namely hypertension, dysli...

F. Kahles, B. Kurt, K. Schneider et al. · 0 citations
Open access Oct 2026

Longitudinal high-sensitivity C-reactive protein assessment predicts cardiovascular risk in apparently healthy individuals

High-sensitivity C-reactive protein (hsCRP) is the guideline-recommended biomarker for assessment of residual inflammatory risk in atherosclerotic cardiovascular disease (ASCVD). Clinical adoption remains limited, especially in individuals without established ASCVD. This study used longitudinal measurements to ev...

B. Kurt, M. Reugels, K. Schneider et al. · 0 citations
Open access Oct 2026

Prognostic impact of high-sensitivity C-reactive protein trajectories and sustained residual inflammation for prediction of cardiovascular outcomes

Traditional risk factors for atherosclerotic cardiovascular disease (ASCVD) fail to fully reflect the residual risk, driven by chronic low-grade inflammation, observed in many. Generally, high-sensitivity C-reactive protein (hsCRP) concentrations remain stable, but some individuals may experience increases. More...

F. Kahles, M. Reugels, K. Schneider et al. · 0 citations
Open access Oct 2026

Comparing the prevalence of cardiovascular inflammation in women and men with atherosclerotic cardiovascular disease with and without chronic kidney disease: a sub-analysis of the POSEIDON study

Cardiovascular (CV) inflammation, defined as high-sensitivity C-reactive protein (hsCRP) ≥2 mg/L, is often present in individuals with atherosclerotic cardiovascular disease (ASCVD) with or without chronic kidney disease (CKD). However, there are limited data regarding disparities in the prevalence of CV inflamma...

G. Liuzzo, J. Amerena, S. Genth-Zotz et al. · 0 citations
Open access Oct 2026

Low-grade chronic inflammation is associated with cardiovascular risk factors but does not improve atherosclerosis stratification by the SCORE2 risk score

Low-grade chronic inflammation is increasingly recognized as a key contributor to cardiovascular disease, yet its incremental value in risk stratification beyond established clinical scores remains uncertain. To evaluate the association between inflammatory biomarkers and cardiovascular risk factors, and t...

A. d'Aiello, F. Jiménez-Trinidad, A. Severino et al. · 0 citations
Review Open access Aug 2026

Heart Failure and Cancer: Incidence and Mortality Patterns, A Systematic Review and Meta-analysis.

The observed HF-cancer association is influenced by statistical methodology, shared risk factors, differences in surveillance intensity and cancer type, that confound analyses investigating possible causal biological links.

L. Sanasi, A. Iaconelli, Danila Azzolina et al. · 0 citations

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