Genetics of Premature Ovarian Insufficiency: From Molecular Architecture to Precision Medicine
Premature ovarian insufficiency (POI) affects 1–3.7% of women and causes infertility and long-term morbidity. Next-generation sequencing has identified more than 130 POI-associated genes. The diagnostic yield of genetic testing depends on cohort size and the quality and scope of the genetic analysis, reaching 29.3% in...