G. Manley

Diagnostic Accuracy of GFAP and UCH-L1 for Acute Intracranial Trauma in a Predominantly Blast-Exposed Cohort of Combat Casualties

Importance There is an urgent need for objective blood tests to guide triage of suspected traumatic brain injury (TBI) in far-forward combat environments, where blast exposure is common and neuroimaging is frequently unavailable. Blood-based glial fibrillary acidic protein (GFAP) and ubiquitin carboxyl-terminal hydrola...

MRI improves global outcome prediction after moderate or severe traumatic brain injury

Natural History and Clinical Associations of Plasma Interleukin-6 Levels in Traumatic Brain Injury

Inflammation following traumatic brain injury (TBI) may contribute to long-term morbidity. We aimed to characterize plasma interleukin-6 (IL6) trajectory after TBI and assess associations with imaging, biomarkers, and outcomes. Secondary analysis of three prospective multicenter observational cohorts: BIO-AX-TBI (Unite...

Multi-dimensional pre-injury health and 6-month outcome after traumatic brain injury in older adults presenting with mainly GCS 13–15

Objective: To test the accuracy of existing traumatic brain injury (TBI) outcome prediction models in older adults with TBI (oaTBI), to determine the independent association of five different measures of pre-injury health with 6-month outcome, and to investigate whether these pre-injury health measures improve outcome...