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Open access Sep 2026

HIF1α-KLF4 signaling dictates extra-erythrocyte expression of hemoglobin conferring sorafenib resistance in hepatocellular carcinoma

Cancer cells must deal with excessive reactive oxygen species (ROS) to survive severe hypoxia and anticancer therapy; however, anti-ROS mechanisms other than the well-known NFE2L2/NRF2 signaling pathway are poorly recognized. Here, we report a ROS scavenging mechanism mediated by HIF1α-KLF4-induced hemoglobin extraeryt...

Bo Zhang, Fei-Chang Liu, Xin-Yue Gao et al. · 0 citations
Review Open access Sep 2026

Hantavirus: biology, immune responses, and pathogenesis

The recent Andes virus (ANDV) outbreak on the MV Hondius cruise has raised global public health alarms due to its dangerous ability to person-to-person spread. Hantavirus infections primarily manifest as hemorrhagic fever with Eurasian renal syndrome (HFRS) and Americas hantavirus cardiopulmonary syndrome (HCPS), bot...

Yu-Fang Shi, Mauro Piacentini, A. Zumla et al. · 0 citations
Open access Jul 2026

SERPINH1 expression represents a reliable biomarker of human breast cancer aggressiveness.

These findings identify SERPINH1 as a marker of ECM-driven tumour aggressiveness and stromal reprogramming in breast cancer and emerges as a promising prognostic biomarker and a tractable therapeutic target in breast cancer.

M. Scimeca, V. Palumbo, F. Servadei et al. · 0 citations

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