Open access
Sep 2026
Structural basis of ligand-selective transcriptional activation in the MerR-family antibiotic resistance regulator AlbA
Multidrug-resistant pathogens demand novel resistance-breaking strategies. The oligoarylamide albicidin and pyrrolobenzodiazepines (PBDs) are potent antibacterials with unrelated scaffolds, yet both are neutralized by albA gene products in many Gram-negatives: AlbA, an albicidin-responsive self-upregulating MerR-family...
M. Di Palma, A. Grinzato, P. Andriollo et al.
· bioRxiv · 0 citations