Limb Ischemia-Reperfusion Injury in Rats is partially mediated by enhancing Necroptosis via Phosphorylation of RIPK1 and MLKL.
Limb ischemia-reperfusion injury (L-IRI) causes severe skeletal muscle damage and functional impairment through activation of regulated cell-death and inflammatory pathways. Necroptosis is a regulated form of necrotic cell death mediated through the receptor-interacting protein kinase 1 (RIPK1)-RIPK3-mixed lineage kina...