641. Microglial osteopontin is required for myelin structural integrity during brain development
Abstract Background Microglia play essential roles in brain development, including regulation of synaptic pruning, phagocytosis, and myelination. A distinct population of white matter–associated microglia at early postnatal development stage in mouse brain expresses high levels of osteopontin (OPN, Spp1), a multifuncti...