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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

G. P. Nagaraju

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Review Aug 2026

From intercellular communication to therapeutic delivery: Mechanistic perspectives of cancer exosomes.

Exosomes, enriched with cancer-specific nucleic acids and proteins, have emerged as key intercellular communicators for orchestrating a tripartite axis of the tumor microenvironment (TME). They contribute significantly to tumor progression, particularly through their involvement in drug resistance, immune suppression,...

RamaRao Malla, G. Nagaraju · 0 citations
Jul 2026

Abstract B005: ADT-030, a novel PDE10 inhibitor that blocks RAS and β-catenin signaling with robust and durable antitumor activity and potential to mitigate resistance and on-target toxicities of monospecific RAS inhibitors

Multiple cancers arise from co-occurring mutations that activate RAS/MAPK and Wnt/β-catenin signaling pathways, which cooperate to drive tumorigenesis, metastasis, and drug resistance. A dual inhibitor of RAS and β-catenin signaling may offer a more effective therapeutic strategy compared with monospecific inhibitors...

Xi Chen, D. Bandi, G. P. Nagaraju et al. · 0 citations
Review Aug 2026

Systemic therapy-induced resistance and toxicity in breast cancer: Sensitization and mitigation strategies.

This review uncovers recent updates on acquired resistance mechanisms toward standard-of-care treatments driven by deeply rooted heterogeneity and aggressive nature and helps to identify novel strategies targeting pathways to reverse resistance and reduce toxicity in breast cancer patients.

Anuveda Sree Samudrala, G. Nagaraju, RamaRao Malla · 0 citations
Jul 2026

Abstract A089: ADT-1004: A mechanistically distinct pan-RAS inhibitor with the potential to escape resistance and mitigate on-target toxicities that limit efficacy and safety of other RAS inhibitors

An orally bioavailable prodrug of ADT-1004, ADT-1004, demonstrated favorable tolerability and suppressed tumor growth in orthotopic and patient-derived xenograft models of pancreatic cancer, accompanied by reductions in activated RAS and p-ERK levels (Mol Cancer, 2025).

Junwei Wang, Xi Chen, Bandi D. S. Reddy et al. · 0 citations

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