Author

G. R. Guimarães

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Open access Sep 2026

Spheroid maturation determines drug response and establishes a mechanism-informed framework for analytical endpoint validation in three-dimensional lung cancer models.

The limited predictive value of conventional two-dimensional (2D) cell culture models remains a major obstacle to successful anticancer drug development. Although three-dimensional (3D) multicellular tumor spheroids better reproduce key structural and functional features of solid tumors, standardized methodologies and...

Jéssica Eduarda dos Santos Batista, Valquíria Silva, F. B. Carvalho et al. · Biomedicine & pharmacotherap... · 0 citations

Open access Aug 2026

Treatment with Alamandine Reduces Established Pulmonary Fibrosis: Preliminary Histological, Functional, and Biochemical Insights

Pulmonary fibrosis (PF) is a challenging interstitial lung disease with limited therapeutic options. This study explores the therapeutic effects of alamandine (ALA), a renin-angiotensin system peptide, in reversing established fibrotic progression in an experimental model. Male Wistar rats were divided into four groups...

Isabel Amaral Martins, Andresa Thomé Silveira, Juliane Flor et al. · International Journal of Pep... · 0 citations