Formulation and Evaluation of Hard Gelatine Capsules of Atorvastatin Prepared by Kneading for Enhancement of Oral Bioavailability
Atorvastatin calcium, a widely prescribed HMG-CoA reductase inhibitor used in the management of hypercholesterolemia and dyslipidaemia, belongs to BCS Class II, characterized by low aqueous solubility and consequently poor and variable oral bioavailability (approximately 12–14%). This limitation arises primarily from p...