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Open access Jul 2026

Integrated Interactomics Reveals Novel Protein Associations: The FOXA1-PBX1 Complex as a Case Study

Protein-protein interactions (PPIs) are fundamental to cellular signaling networks, yet many remain undetected due to technical limitations of individual affinity purification approaches. To address this, we systematically mapped the interaction landscapes of six regulatory proteins involved in cell proliferation, immu...

Zhi Chen, Istvan Szepesi-Nagy, Qingyue Zhang et al. · 0 citations
Open access Jul 2026

Pan-cancer proteogenomic interrogation of the ubiquitin-proteasome system.

Somatic mutations rewire the ubiquitin-proteasome system (UPS) to support tumor growth, but the proteome-wide consequences of cancer-driver alterations on UPS composition remain incompletely understood. Using harmonized proteogenomic data from up to 11 CPTAC cohorts, we performed an integrated pan-cancer analysis of UP...

Tania J. González-Robles, Maha Khan, Paul Sastourné et al. · 0 citations

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