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G. S. Dawe

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Sep 2026

Targeting CH25H restores p62-mediated α-synuclein clearance.

Astrocytes remove extracellular α-synuclein aggregates through p62-dependent autophagy, yet the factors limiting this defense remain unclear. Zhang and colleagues recently identified cholesterol 25-hydroxylase as an inducible negative regulator of p62-mediated clearance. Genetic suppression or a p62-derived decoy pepti...

G. S. Dawe · 0 citations

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