Bioactive Ion-Doped Monetite/Chitosan Thermosensitive Hydrogels with Dual Osteogenic and Pro-Angiogenic Stimuli for Bone Regeneration.
It is demonstrated that ionic doping confers distinct and complementary bioactivities to monetite, pro-angiogenic/migratory Co2+, and osteogenic/matrix-synthetic Mg2+, and that chitosan hydrogels represent an injectable vehicle that amplifies bioactive signaling upon direct cell contact, thus offering a versatile and i...