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Author

G. Sadri-Vakili

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Open access Aug 2026

Functional Activity of TDP-43: A Direct Biomarker for ALS

A serum-based homogeneous time-resolved FRET (hTR-FRET) assay that quantifies TDP-43 RNA binding activity using synthetic UU-rich RNA probes provides a proof-of-concept platform for the direct functional measurement of probe-competent TDP-43 species in serum.

K. Sonkar, Vito Levi D'Ancona, Jade Cramp et al. · 0 citations
Open access Jul 2026

Tau isoform imbalance and aggregation are pathological hallmarks of X-linked dystonia-parkinsonism

It is reported that X-linked Dystonia-Parkinsonism (XDP), caused by a non-coding retrotransposon-associated repeat insertion in TAF1, involves a significant imbalance of tau isoforms and the accumulation of hyperphosphorylated, four-repeat tau in the brain.

C. J. Reyes, Aloysius Domingo, E. Penney et al. · 0 citations

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