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G. Sani

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Open access Oct 2026

Managing coexisting depression and substance use disorder: insights from clinical experience

Comorbid major depressive disorder (MDD) and substance use disorder (SUD) occur frequently and are challenging to manage. The negative impact of these co-occurring conditions on patient quality of life, functional ability, and mortality necessitates timely diagnosis and a multifaceted treatment approach. However, there...

Fabrizio Schifano, G. Martinotti, M. Wojnar et al. · 0 citations
Open access Sep 2026

Reduced Anticipatory Pleasure in Early-Onset Severe Cannabis Use Disorder: A Retrospective, Cross-Sectional Study

Background: Cannabis is the most widely used illicit substance, particularly among youth. Earlier onset is associated with poorer clinical trajectories in cannabis use disorder (CUD), but its relationship with hedonic–motivational components remains unclear. Methods: Outpatients with severe CUD (n = 121) were stratifie...

M. Pepe, Francesco Traccis, G. Mandracchia et al. · 0 citations
Review Open access Sep 2026

Different psychological and quality-of-life outcomes after subthalamic nucleus deep brain stimulation in Parkinson's disease patients: a prospective study.

BACKGROUND The present study aimed to evaluate changes in hopelessness, psychological well-being, and quality of life following subthalamic nucleus deep brain stimulation (STN-DBS) in patients with Parkinson's disease (PD). In addition, a secondary exploratory aim was to assess the role of anxiety and depression as pre...

Marianna Mazza, G. Marano, Giorgio Veneziani et al. · 0 citations
Review Open access Sep 2026

Psychiatric symptoms in gliomas: a systematic review

Psychiatric symptoms are prevalent among adults with gliomas, yet their recognition and characterization remain limited. This systematic review aimed to synthesize evidence on prevalence, temporal course, and disease-specific correlates of all reported psychiatric symptoms in adults with glioma. Pub...

Francesca Bardi, L. Monacelli, R. Caso et al. · 0 citations
Review Open access Sep 2026

Lithium for Radiation-Induced Damage in Pediatric Brain Tumors: Preclinical Evidence and Clinical Perspectives

The preclinical basis and emerging clinical evidence for lithium as a potential adjunct to radiotherapy while discussing key unresolved issues, including optimal timing, treatment duration, tumor safety, and patient selection are summarized.

Francesca Bardi, Antonio Restaino, C. Calderoni et al. · 0 citations
Open access Sep 2026

From real-world experience to precision prescribing of antidepressants: a machine-learning analysis of clinicians' treatment choices.

This study examined whether psychiatrists' routine prescribing decisions could be used to identify practice-grounded patterns supporting precision-oriented treatment selection, and found that similarity-based models may provide a more conceptually coherent approach.

Francesco Calabró, Claudio Caiazza, U. Albert et al. · 0 citations
Review Open access Aug 2026

Evaluating seltorexant as a treatment option for major depressive disorder

Seltorexant 20 mg has shown a promising antidepressant effect, particularly in patients with clinically significant insomnia, and a favorable tolerability profile, and the mixed phase-3 results, the modest effect sizes, and gaps on core symptoms of depression warrant a measured positive view, pending confirmatory data.

M. Di Nicola, M. Pepe, I. Marcelli et al. · 0 citations
Open access Jul 2026

Emotional and Behavioral Profiles in Neurodevelopmental and Neuromuscular Disorders: A Comparative Study Using the Child Behavior Checklist

Children with ADHD showed the highest overall emotional–behavioral burden, whereas ASD and SLD were characterized by greater internalizing difficulties and DMD by a distinct emotional–behavioral profile, using the same standardized CBCL/6–18 assessment.

D. P. Chieffo, Federica Moriconi, Valentina Delle Donne et al. · 0 citations

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